“Activation of nicotinic cholinergic receptors prevents ventilator-induced lung injury in rats.”

“Respiratory distress syndrome is responsible for 40 to 60 percent mortality. An over mortality of about 10 percent could result from additional lung injury and inflammation due to the life-support mechanical ventilation, which stretches the lung. It has been recently demonstrated, in vitro, that pharmacological activation of the alpha 7 nicotinic receptors (α7-nAChR) could down regulate intracellular mediators involved in lung cell inflammatory response to stretch.”

*puff*

http://www.ncbi.nlm.nih.gov/pubmed/21857926

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