“Top Selling Medical Device Standards”

Document Center, Inc.
http://www.document-center.com/standards/subjects/medicalstds

“NEUROTECHNOLOGY RESEARCH, DEVELOPMENT, AND ENHANCEMENT”

Release Date: October 2, 2001
“Summary

This PA is expected to advance understanding of the nervous system through
support of research, development, and enhancement of a wide range of
neurotechnologies. Examples of hardware, software, and wetware useful for
neuroscience that would be considered appropriate under this PA for research,
development and enhancement include but are not limited to:

o Microelectromechanical system (MEMS) devices used for monitoring neuron
function in slice and culture preparations

o Amplifiers that are small and light enough to be worn by mice for
recording neural activity from many neurons

o Improved electrodes, microcomputer interfaces, and microcircuitry for
chronic implantation, monitoring of neural activity, and promoting efferent
function

o Dynamic monitors of intracranial pressure and cerebral spinal fluid
composition (particularly important in following disease progression or
recovery from brain injury)

o Devices for non-invasive diagnosis and precise identification of pathogens
involved in central and peripheral neural infectious diseases

o Tools for relatively non-invasive ways to assess damage and monitor
function in regions of injured or diseased brain tissue

o Proteome analysis arrays, proteome data storage and analysis of proteome
data from the nervous system

o Microfluidic systems for in-vivo spatial and temporal controlled delivery
of neurotransmitters and other biomolecules

o Delivery systems for exogenous agents such as drugs, gene transfer
vectors, and cells

o Non-invasive methods for in-vivo tracking of implanted cells

o Tools for real-time analysis of neurophysiological events

o Technologies for detection, intervention, and prevention of acute, adverse
neurological events

o Tools for early-warning detection of imminent seizure activity;
application of targeted treatment to abort seizures

o Tools for therapeutic electrical stimulation for rehabilitation following
stroke, trauma or other events or disorders that disrupt normal function of
the nervous system

o Telemetry devices small and light enough to be worn by mice for
transmitting data (e.g., electrophysiological data) during behavior

o Biosensors that would be selectively activated by neurochemicals, such as
particular neurotransmitters or pharmacological compounds

o Software to translate neuroimaging data from one data format into another

o Tools for data mining for genetic discovery and functional insights into
genomics and proteomics of the nervous system

o Algorithms that use shape analysis approaches to understand human
neuroimaging data

o Tools to enhance visualization of specific brain markers

o Computational approaches to analyzing video data (like those used in
behavioral research)

o Computational approaches and improved paradigms for analysis of kinematic
data

o Nanocrystals or quantum dots covalently bonded to neural receptor ligands

o Probes of brain gene expression that can be imaged non-invasively (e.g.,
with magnetic resonance or near infrared optical imaging)

It is stressed that the examples given above are not meant to be exhaustive,
they are merely given to suggest the kinds of projects that would be
appropriate.”
http://grants.nih.gov/grants/guide/pa-files/PA-02-003.html

*pro·te·ome (prt-m)
n.
1. The set of proteins expressed by the genetic material of an organism under a given set of environmental conditions.
2. The complete set of proteins that can be expressed by the genetic material of an organism. Also called complete proteome.

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